Heartworm can be a silent killer because it will go unnoticed by owners most of the time. Heartworm larvae are transmitted by infected mosquitoes. When the infected mosquito bites, the larvae pass through the tissue into the bloodstream. It’s virtually impossible to stop mosquitos from biting your fur babies, so pet owners need to protect them against heartworm.
For dogs 6 weeks old and older with no weight requirement.
Dosage Schedule
Body Weight
Chewable Per Month
Ivermectin Content (mcg)
Pyrantel Content (mg)
Color Coding
Up to 25 lbs (11 kg)
One
68
57
Blue
26 to 50 lbs (12-22 kg)
One
136
114
Green
51 to 100 lbs (23-45 kg)
One
272
227
Brown
Over 101.0 lbs (46 kg)
Administer the appropriate combination of chewables
Heartgard Plus chewables should be chewed, not swallowed whole. The chewables may be broken into pieces and fed to dogs that normally swallow treats whole.
Heardgard Pluscan be taken together with NexGard for all-round protection against fleas and ticks.
The reported adverse reactions are: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.
Heartgard Plus may cause sensitivities in certain dogs of the herding breeds. Please consult your veterinarian before administering them to your pet.
What special precautions are there?
Do not give Heartgard Plus to your pet if it is taking another heartworm medication.
How safe is Heartgard Plus (ivermectin/pyrantel)?
Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with Heartgard Plus in a heartworm disease prevention program.
